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treatment for metastatic adenocarcinoma

Saeedrezaei
Posts: 1
Joined: Nov 2003

Dear All,
I have been diagnsed with metastatic adenocarcinoma. It initially started with teratocarcinoma.
I am wondering if anyone can help me with an effective treatment solution.
cheers,
saeed

rockgirl
Posts: 3
Joined: Nov 2003

My husband was diagnosed with adenocarcinoma, unknown primary in June 2003. We finally are receiving treatment at Cancer Treatment Centers of America in Zion, IL, even tho we live in Indiana. He will be undergoing his 5th round of chemo mid-November and is doing very well. Drs here at 3 hospitals in Indiana, gave him 2-6 months and not good months. He has had pain, mets are to spine and lymph nodes but he is responding very well to the treatment plans we have and pain meds have been reduced to the point where he can now drive the car for short trips. Chemo does zap his strength so his energy levels are lower than normal but hey, he is alive and has at least 3 good weeks every month. We currently are using acupuncture to help with side effects after chemo and its working wonderfully! Where are you being treated?

meggyjelly
Posts: 1
Joined: Nov 2003

my dad was just diagnosed. it's nice to know someone else out there is doing well. i was wondering about the drugs he had for chemotherapy because my dad is in the decision making stage over treatments. any advice would be greatly appreciated. thanks! meghan email md2311@ship.edu

EllenG
Posts: 2
Joined: Dec 2003

I have adenocarinoma, unknown primary having been diagnosed in 9/98. I had chemo, my lung removed, and radiation. I was in remission for 2 1/2 years, then had mets to the liver which has recurred 4 times. I've maintained on chemo cocktails for the past 3 years.

rockgirl
Posts: 3
Joined: Nov 2003

please tell me more about your cancer battle. My husband is in month 6 of chemo for adenocarcinoma unknown primary. We are getting 2nd PET scan done in 2 days to find out if we are winning. He was just diagnosed in June 03 and his CEA is at 11.5 now. It began at near 1600. That is only tumor marker they are using which concerns me but all others didn't show anything abnormal. They initially showed 3 lesions in his liver and since he was stage 4, they have only concentrated on mass retro perioteneum and nothing about liver. I am worried its going to get away from them but they seem unconcerned. What do I do?

ladybug626's picture
ladybug626
Posts: 32
Joined: Dec 2003

Hello,

My Mom is being treated for stage IV metastatic adenocarcinoma that originated in the uterus. She has completed 3 rounds of chemo ( taxol + carboplatin) so far. The oncologist probably seems unconcerned about the liver because the chemo travels everywhere. They may be focused on the mass in the retro perioteneum, but if the chemo is working there it is probably working on the lesions in the liver also. In my Mom's case, they took the same approach and the chemo is working on the tumor in the uterus and the nodules in her lung. I hope you receive a good report after the second PET scan. My Mom did not see an improvement until her 2nd scan. You sound positive and hopeful which is major blessing for your husband. It is not always easy to stay positive, but it makes an unbelievable difference. Good nutrition, guided imagery, and relaxation tapes also improved her health (physically & mentally). Although the chemo is working well, we are seeking a second opinion about her treatment plan. Stage IV disease is serious so we want to be sure we are utilizing the best combination of treatments available. If you receive a negative prognosis, please don't be discouraged. Doctors are often wrong about prognoses and so much depends on the individual. I hope this information helped. Best wishes to you. We'll keep you and your husband in our prayers.

shugu12
Posts: 4
Joined: Jan 2012

My mum had a hysterectomy in 2008.She had complained about heavy bleeding during her periods. On diagnosis we found there was a fibroid growth in the uterus. The gynecologist suggested to remove the uterus and the ovaries. After the hysterectomy,the fibroid was given for biopsy which resulted to be negative for malignancy test. In April 2011 she developed the symptoms of severe back ache and loose motion. On diagnosis we got to know about the metastatic Adenocarcinoma. The primary was unknown and still is. She has undergone 6 cycles of chemotherapy( taxol + carboplatin).She had CA-125 level up to 310 which got increased up to 698 after the first cycle of chemo. From there it got down to 63 after 6 cycles of chemo. Currently she is on oral Chemotherapy(Xeloda - 500mg). After 6 cycles of chemo the latest PET CT scan shows metastasis to bilateral pelvic lymph nodes, retro peritoneal lymph nodes,right retrocrural lymph node, omen-tum and left adrenal gland. Doctors are not sure of the surgery.If the surgery will help her. Could you help? My case looks similar to your mum's case.Anybody who knows anything about this please help me.Any info you guys have might help me.

TEX744
Posts: 1
Joined: Feb 2004

Hi. I was diagnosed adeenocarcinoma no primay 11/19. What chemo cocktails have you folks had luck with???

gdpawel's picture
gdpawel
Posts: 549
Joined: May 2001

Chemosensitivity Testing

One approach to individualizing patient therapy is chemosensitivity testing. Chemosensitivity assay is a laboratory test that determines how effective specific chemotherapy agents are against an individual patient's cancer cells. Often, results are obtained before the patient begins treatment. This kind of testing can assist in individualizing cancer therapy by providing information about the likely response of an individual patient's tumor to proposed therapy. Chemosensitivity testing may have utility at the time of initial therapy, and in instances of severe drug hypersensitivity, failed therapy, recurrent disease, and metastatic disease, by providing assistance in selecting optimal chemotherapy regimens.

All available chemosensitivity assays are able to report drug "resistance" information. Resistance implies that when a patient's cancer cells are exposed to a particular chemotherapy agent in the laboratory, the cancer cells will continue to live and grow. Some chemosensitivity assays also are able to report drug "sensitivity" information. Sensitivity implies that when a patient's cancer cells are treated with a particular chemotherapy agent in the laboratory, that agent will kill the cancer cells or inhibit their proliferation.

The goal of all chemosensitivity tests is to determine the response of a patient's cancer cells to proposed chemotherapy agents. Knowing which chemotherapy agents the patient's cancer cells are resistant to is important. Then, these options can be eliminated, thereby avoiding the toxicity of ineffective agents. In addition, some chemosensitivity assays predict tumor cell sensitivity, or which agent would be most effective. Choosing the most effective agent can help patients to avoid the physical, emotional, and financial costs of failed therapy and experience an increased quality of life.

Fresh samples of the patient's tumor from surgery or a biopsy are grown in test tubes and tested with various drugs. Drugs that are most effective in killing the cultured cells are recommended for treatment. Chemosensitivity testing does have predictive value, especially in predicting what "won't" work. Patients who have been through several chemotherapy regimens and are running out of options might want to consider chemosensitivity testing. It might help you find the best option or save you from fruitless additional treatment. Today, chemosensitivity testing has progressed to the point where it is 85% - 90% effective.

Listing of "Reputable" Labs USA:

These labs will provide you and your physician with in depth information and research on the testing they provide.

Analytical Biosystems, Inc., Providence, Rhode Island. Ken Blackman, PhD. Solid Tumors Only. 1-800-262-6520

Anticancer, Inc., San Diego, CA. Robert Hoffman, PhD. Solid Tumors Only. 1-619-654-2555

Oncotech, Inc., Irvine, CA. John Fruehauf, MD. Solid Tumors and Hematologics. 1-714-474-9262 / FAX 1-714-474-8147

Sylvester Cancer Institute, Miami, FL. Bernd-Uwe Sevin, MD. Solid Tumors Only. (especially GYN). 1-305-547-6875

Human Tumor Cloning Laboratory, San Antonio, TX. Daniel D. Von Hoff, MD. Solid Tumors Only. 1-210-677-3827

Rational Therapeutics Institute, Long Beach, CA. Robert A. Nagourney, MD Solid Tumors and Hematologics. 562-989-6455 http://www.rational-t.com/

Weisenthal Cancer Group, Huntington Beach, CA. Larry M. Weisenthal, MD, PhD. Solid Tumors and Hematologics. 1-714-894-0011 / FAX 1-714-893-3659 / e-mail: mail@weisenthal.org

Angiogenesis & Low Dose Chemotherapy

Giving low doses of several drugs every day by mouth. There would be no needles and the side effects are expected to be mild. Unlike standard chemotherapy, which is given in high doses to kill as many cancer cells as possible, the lower-dose regimen is meant to attack the blood vessels that feed the tumor. Tumors create their own supply lines by secreting substances that stimulate the formation of new blood vessels and researchers suspect that frequent low doses of certain drugs may disrupt the growth of those new vessels, starving the tumor.

The treatment includes small daily doses of standard chemotherapy drugs and two other drugs that have been found to inhibit the formation of new blood vessels, called angiogenesis. One is Celebrex and the other is Thalidomide. It is offered only to people who have no other options, who have advanced tumors that standard treatment cannot cure or those for whom standard chemotherapy has quit working.

Women with advanced breast or ovarian cancer are being given smaller, more frequent doses of chemotherapy to reduce side effects. It is hoped that low-dose treatment may help other cancer patients, not just those who are considered terminal. It may work just as well or even better, maybe through this ability to cause an anti-angiogenesis effect.

This approach to treatment is based on something that can frequently occur in people, when a tumor becomes resistant to chemotherapy and high doses stop working. It is believed that angiogenesis plays a role. Angiogenesis is essential to the survival of many tumors. Many chemotherapy drugs, in addition to killing tumor cells, also fight angiogenesis. But, if these medicines stop angiogenesis, chemotherapy should work better than it does. Blood vessel cells are less likely than tumor cells to become resistant to chemotherapy, so if cancer cells become drug resistant, these medicines should still be able to shrink tumors by destroying their blood supply.

The reason chemotherapy was not stopping angiogenesis was that chemotherapy is usually given in big doses, with breaks of several weeks between doses to let the body recover. During the breaks, the tumor's blood vessels could grow back. By giving chemotherapy more often, at lower doses, it might prevent the regrowth of blood vessels and kill the tumor or at least slow its growth.

It is especially important to study low-dose therapies now because they are being used increasingly in clinics. Doses, timing and combinations all need to be worked out. Doctors need to find out whether the treatments can make patients live longer and whether tumors will eventually outsmart the drugs and find ways to survive even without angiogenesis.

For further information about clinical trials, refer to the National Cancer Institute's website: (http://cancertrials.nci.nih.gov)

jonanner47
Posts: 1
Joined: Oct 2013

My husband has been diagnosised with metastatic adenocarcinoma and have started chemo camptosar/oxaliplatin and 5-FU and Leucovorin. Any info would be appreciated. We are struggling with stopping chemo and go with a Dr Russ Bianchi. Has anybody heard about him and Moringa plant and Zija.

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