My dad is 47 and diagnosed with stage iv in June 2003. He had surgery to remove colon tumor and mets to liver is inoperable. He is a fighter, and we are not giving up- but it seems odd that after just 4 treatments of oxi they decided to change him to cpt-11. He has had alot of fluid buid up in the belly, so maybe they are changing because it is known to damage the liver (cause for fluid). CT scans showed that the liver looked the same at the time of diagnosis but because people have had shrinkage w/ the oxi- I wonder if its a hasty decision (started chemo on 7/1/03), or are they being aggressive and I should be glad???. Anyone out there that can advise?? Please respond if you can- thank you and BEST wishes to everyone!