Scan results- Clean!!

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  • NanoSecond
    NanoSecond Member Posts: 653
    #22
    todd121 said:

    Everolimus

    By the way, not to be picky, but just trying to help with accuracy.

    Everolimus was not designed to prevent recurrence of cancer. In fact, it wasn't designed to be a cancer drug at all, at least to my understanding. It was first used and is still mostly used to prevent rejection of transplanted organs like kidneys and hearts. I can't say how or why they decided to try it on kidney cancer, but that came later. It's currently only FDA approved as a kidney cancer treatment after failure of some other drugs like Sutent. It is used for some other cancer (I don't remember which one) and it is also used in some stints to keep blood clots from forming in the stints.

    They don't know if it will prevent kidney cancer. That's the purpose of the Everest study: to see if it might delay or prevent recurrence.

    Todd

    Heads up

    Hi Todd.  The mTOR inhibitors all play a key regulatory role in immune response.  That is why they initially were (and still are) employed in transplate operations.  But do keep in mind that this means they may be immune suppressive depending on the circumstance.

    I am not sure if I sent this to you once before or not.  It's a heads up that you might want to discuss with your oncologist in case he was unaware of it:

    http://annonc.oxfordjournals.org/content/early/2013/06/23/annonc.mdt233.abstract

    You may have to wait a bit for it to load.  It's worth the wait.

  • todd121
    todd121 Member Posts: 1,448 Member
    #23
    NanoSecond said:

    Heads up

    Hi Todd.  The mTOR inhibitors all play a key regulatory role in immune response.  That is why they initially were (and still are) employed in transplate operations.  But do keep in mind that this means they may be immune suppressive depending on the circumstance.

    I am not sure if I sent this to you once before or not.  It's a heads up that you might want to discuss with your oncologist in case he was unaware of it:

    http://annonc.oxfordjournals.org/content/early/2013/06/23/annonc.mdt233.abstract

    You may have to wait a bit for it to load.  It's worth the wait.

    Everolimus Adverse Reactions

    Thanks. I've printed it out and I'll hand a copy to my oncologist tomorrow.

    I went back and looked at the list of possible adverse reactions, and I do see a 3% occurrence of renal failure listed and there's a 16% higher incidence of increased creatinine than with placebo.

    They are taking blood and monitoring every 6 weeks (creatinine, GFR, lipids, blood sugar, etc). I suppose that's why. My creatinine was up slightly last time around and I'm hoping it's same or reduced tomorrow. I'm going to make sure to drink plenty of water this time. I have in the past, but I did not this past time.

    Todd

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