Is anyone in the LY2875358 trial?

Phoenix Rising
Phoenix Rising Member Posts: 170

Hey team,

So my scans from almost two weeks ago show mixed results.  Some nodules on my lungs grew just slightly, some did not change at all, and the enlarged hilar lymph node is the same.  My oncologist thinks it is time to move on, and wants me to consider the LY2875358/anti- c-met antibody trial.  I think this is the former MDX1106/BMS936558 trial.  The patient information only lists a few side effects, including nausea, diarrhea, accelerated heart rate and possibly enlarged thyroid.  I'd like to hear more about this from anyone in the trial, or from anyone who is just in the know.  Thanks!

Oh, and it turns out that the extra pain I felt in my neck and back, you know, the pain we always think is more cancer.... well I got a new memory foam pillow and guess what-- no neck and back pain.

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Comments

  • garym
    garym Member Posts: 1,647
    2 with good result...

    Fox was our MDX poster boy until recently switching to IL-2, but I'm pretty sure you know his story, he had very few side effects at all.  Alice's husband John (one putt) is doing well in the MDX/Votrient trial I believe.

  • MDCinSC
    MDCinSC Member Posts: 574
    Lets hear it for memory foam

    Lets hear it for memory foam pillows!  Cool

     

    Sounds like an investment I need to make!

  • foxhd
    foxhd Member Posts: 3,181 Member
    MDCinSC said:

    Lets hear it for memory foam

    Lets hear it for memory foam pillows!  Cool

     

    Sounds like an investment I need to make!

    MDX-1106

    I was on it for about 18 months and had virtualy no side effects. Fatigue some times. But it was soooo easy. In the end it just couldn't clear up some bone mets although it did clear them initially. I say go for it. Other drugs will be available later.

  • Texas_wedge
    Texas_wedge Member Posts: 2,798
    garym said:

    2 with good result...

    Fox was our MDX poster boy until recently switching to IL-2, but I'm pretty sure you know his story, he had very few side effects at all.  Alice's husband John (one putt) is doing well in the MDX/Votrient trial I believe.

    MDX-1106 => HD IL2

    I wonder whether we'll ever get to know the transfer fee. 

    Anyway, I bet his new club is already confident that they're on to a winner.!

  • Darron
    Darron Member Posts: 310 Member
    Not sure it is the same

    I do not think it he LY2875358 and the MDX/BMS936558 are the same trial drugs. The LY (from what I read) is blocking a different receptor. I'm not a doctor and I didn't stay at a Holiday Inn, so I could be wrong.

  • Texas_wedge
    Texas_wedge Member Posts: 2,798
    Botticelli nothing!

    So now we have another iconic vision to entertain - Phoenix Rising from the foam!

    So glad that the new 'cancer pain' was so easily solved.  It's an answer that may help a lot of other folks who have had the same experience of troublesome and anxiety-provoking pains.

  • Phoenix Rising
    Phoenix Rising Member Posts: 170
    garym said:

    2 with good result...

    Fox was our MDX poster boy until recently switching to IL-2, but I'm pretty sure you know his story, he had very few side effects at all.  Alice's husband John (one putt) is doing well in the MDX/Votrient trial I believe.

    Being side-effect free would make me happy!

    This trial is a monotherapy, so I would only be taking the LY thing, without Votrient or any other combos and cocktails.  I know One Putt’s story, but I am going to try to go back and read again.  The possibility of no side effects makes me happy and excited.  Votrient and I cannot agree on a good hair color, and the high blood pressure gave me the runaround with some terrible headaches and nausea once.

  • Phoenix Rising
    Phoenix Rising Member Posts: 170

    MDX-1106 => HD IL2

    I wonder whether we'll ever get to know the transfer fee. 

    Anyway, I bet his new club is already confident that they're on to a winner.!

    Surgery=>More surgery=>IL2=>Votrient=>LY stuff

    ^^ With a history like that, I should collect a transfer fee!

  • Phoenix Rising
    Phoenix Rising Member Posts: 170
    MDCinSC said:

    Lets hear it for memory foam

    Lets hear it for memory foam pillows!  Cool

     

    Sounds like an investment I need to make!

    Loving the foam!

    I paid $24.99 U.S. for the pillow... a pittance to pay for relief from "cancer pain." Cool

  • Phoenix Rising
    Phoenix Rising Member Posts: 170
    Darron said:

    Not sure it is the same

    I do not think it he LY2875358 and the MDX/BMS936558 are the same trial drugs. The LY (from what I read) is blocking a different receptor. I'm not a doctor and I didn't stay at a Holiday Inn, so I could be wrong.

    I thought something way different

    I thought that each time the study drug passes a phase, the name changes.... like BMS means it's Bristol Meyers Squibb, and LY is for Eli Lily and Company, or that the name changes based on the sponsor, collaborator, or party responsible for the trial.  I don't really know a lot, but I did save money on my car insurance.

  • Phoenix Rising
    Phoenix Rising Member Posts: 170

    Botticelli nothing!

    So now we have another iconic vision to entertain - Phoenix Rising from the foam!

    So glad that the new 'cancer pain' was so easily solved.  It's an answer that may help a lot of other folks who have had the same experience of troublesome and anxiety-provoking pains.

    Eureka!

    I discovered the "cure" pretty much by accident.  I went on a short vacation this week, and woke up with neck and back pain worse than what I had been experiencing the past couple of months.  It was suggested that I sleep without the pillow.  I tried that and felt much better the next day.  As soon as I got home, I bought the memory foam and yes, I rose from the foam!

  • angec
    angec Member Posts: 924 Member

    Botticelli nothing!

    So now we have another iconic vision to entertain - Phoenix Rising from the foam!

    So glad that the new 'cancer pain' was so easily solved.  It's an answer that may help a lot of other folks who have had the same experience of troublesome and anxiety-provoking pains.

    Yes TW, exactly what DHS has

    Yes TW, exactly what DHS has experienced, there was no disease progression on his new scans, he was worried like crazy with pains in his belly!  Glad for both he and Phoenix!  Memory foam, schememory foam! LOL

  • Phoenix Rising
    Phoenix Rising Member Posts: 170
    Lucky to get LY2875358?

    My oncologist told me God must be on my side because there were only 5 slots for this trial in this region, and I got a slot when someone else dropped off the list.  He did not know what caused the other person to leave the trial but he believes they left before they even started the trial. He is very confident this will work well for me.

     

     

     

     

  • Texas_wedge
    Texas_wedge Member Posts: 2,798

    Lucky to get LY2875358?

    My oncologist told me God must be on my side because there were only 5 slots for this trial in this region, and I got a slot when someone else dropped off the list.  He did not know what caused the other person to leave the trial but he believes they left before they even started the trial. He is very confident this will work well for me.

     

     

     

     

    Lucky?

    Lucky, maybe, but also a very worthy recipient and I'm sure his confidence is well-placed.

  • Darron
    Darron Member Posts: 310 Member

    Lucky to get LY2875358?

    My oncologist told me God must be on my side because there were only 5 slots for this trial in this region, and I got a slot when someone else dropped off the list.  He did not know what caused the other person to leave the trial but he believes they left before they even started the trial. He is very confident this will work well for me.

     

     

     

     

    No bad decisions

    When I was asked to either asked to enter the trial, my doctor said something that I think is very wise.

    if the trial doesn't provide what we hope for, then we have another decision to make. Do not think of it as failing, think of it as just another decision in the figsexism my Ming it is a decision to fight!

  • alice124
    alice124 Member Posts: 896 Member

    I thought something way different

    I thought that each time the study drug passes a phase, the name changes.... like BMS means it's Bristol Meyers Squibb, and LY is for Eli Lily and Company, or that the name changes based on the sponsor, collaborator, or party responsible for the trial.  I don't really know a lot, but I did save money on my car insurance.

    Trial

    Wow Phoenix - if that's the case, you've taught me something new. (Not that I don't have a lot to learn Embarassed.) I had never heard that take on name changes based on phase and sponsor. Out of curiosity, I googled the two and while BMS936558 and MDX1106 consistently cross referenced each other in writeups, I didn't see the same for the Ly2875358. 

     

    LY2875358 ) anti-c-MET monoclonal antibody LY2875358 

    BMS-936558 (an anti-programmed death-1 (MDX-1106)

     

    But if you have confidence in  your doctor, and he has confidence that this is the right trial for you, ride like the wind to get there. If it is the same trial as John is on minus the Votrient, I think you can anticipate few side effects. (I bet you'll still be able to wear those pretty shoes!) It's nothing like the IL2. Go for it!

    Btw, where will you be treated?

     

     

     

     

     

     

  • Texas_wedge
    Texas_wedge Member Posts: 2,798

    I thought something way different

    I thought that each time the study drug passes a phase, the name changes.... like BMS means it's Bristol Meyers Squibb, and LY is for Eli Lily and Company, or that the name changes based on the sponsor, collaborator, or party responsible for the trial.  I don't really know a lot, but I did save money on my car insurance.

    Drug names

    Phoenix, you do seem to have got yourself awfully confused over the trial you're talking about, over the trials process, and over drug names.  I hope I can clarify matters for you.

    The trial that was being suggested to you has nothing whatsoever to do with the MDX-1106 trial Fox was on. Nor is the drug in any way connected - different manufacturers, different chemistry, different drug, different generation of drug also, and different trial stage.  This trial is for what I believe is a third generation humanised monoclonal antibody agent - i.e. some way on from Fox's famous trial drug which is an immunomodulator of the same kind, and it represents a me-too attempt by another rival to cash in on the spectacular early promise of MDX-1106. 

    [The various big pharma concerns are always busy trying to avoid any of their number getting the drop on the rest with a runaway success going unchallenged.  To a great extent it's a 'zero-sum game' - one gains at the extent of the others in competing to meet each particular need.  It's a dog-eat-dog world with such mammoth R & D costs that each company is at times at risk of going over the patent cliff as the deadline for their big money-spinners approaches and the legal protection expires which prevents anyone else from producing it at a knock-down price.]

    You can get a lot of useful information about the drug which is the subject of the trial proposed for you at

    http://www.prnewswire.com/news-releases/lilly-targets-faulty-c-met-receptor-in-cancer-research-studies-presented-today-at-aacr-meeting-145788385.html

    When a drug is at an experimental stage prior to trial and (it's hoped approval later on) it's usually given a pretty anodyne label - typically alphabetic - abbreviation of the company's name - plus a number (normally just the next one sequentially in their development lists.  So, for 'your' trial Eli Lilly have called it LY + a reference no.

    The history of 'Fox's' drug is that it as developed in East and West.  In the West it was made by Medarex - hence the earlier moniker MDX.     Medarex was bought out by Bristol Myers Squibb who thereupon re-named it for their co. as BMS.  Meanwhile it was developed and sold in 3 Asian countries by Ono Pharmaceuticals who, of curse, labelled it ONO.  Meanwhile, the assignment of an official generic name was in progress and this emerged last year as "nivolumab".  It will continue to be so called as a chemical name but doubtless after it gains FDA approval (it seems highly improbable that it won't!!) the manufacturers will invent brand names for it.  I say names becaus if the present licence arrangement continues it will be going out from separate makers in east and west.

    I hope this clears it up for you and I hope you stay well and continue to save money on car insurance.  Laughing

  • Texas_wedge
    Texas_wedge Member Posts: 2,798
    Darron said:

    No bad decisions

    When I was asked to either asked to enter the trial, my doctor said something that I think is very wise.

    if the trial doesn't provide what we hope for, then we have another decision to make. Do not think of it as failing, think of it as just another decision in the figsexism my Ming it is a decision to fight!

    ?

    Am I losing it more than I realised or were you on something when you composed that message Darron? Smile

  • alice124
    alice124 Member Posts: 896 Member

    Drug names

    Phoenix, you do seem to have got yourself awfully confused over the trial you're talking about, over the trials process, and over drug names.  I hope I can clarify matters for you.

    The trial that was being suggested to you has nothing whatsoever to do with the MDX-1106 trial Fox was on. Nor is the drug in any way connected - different manufacturers, different chemistry, different drug, different generation of drug also, and different trial stage.  This trial is for what I believe is a third generation humanised monoclonal antibody agent - i.e. some way on from Fox's famous trial drug which is an immunomodulator of the same kind, and it represents a me-too attempt by another rival to cash in on the spectacular early promise of MDX-1106. 

    [The various big pharma concerns are always busy trying to avoid any of their number getting the drop on the rest with a runaway success going unchallenged.  To a great extent it's a 'zero-sum game' - one gains at the extent of the others in competing to meet each particular need.  It's a dog-eat-dog world with such mammoth R & D costs that each company is at times at risk of going over the patent cliff as the deadline for their big money-spinners approaches and the legal protection expires which prevents anyone else from producing it at a knock-down price.]

    You can get a lot of useful information about the drug which is the subject of the trial proposed for you at

    http://www.prnewswire.com/news-releases/lilly-targets-faulty-c-met-receptor-in-cancer-research-studies-presented-today-at-aacr-meeting-145788385.html

    When a drug is at an experimental stage prior to trial and (it's hoped approval later on) it's usually given a pretty anodyne label - typically alphabetic - abbreviation of the company's name - plus a number (normally just the next one sequentially in their development lists.  So, for 'your' trial Eli Lilly have called it LY + a reference no.

    The history of 'Fox's' drug is that it as developed in East and West.  In the West it was made by Medarex - hence the earlier moniker MDX.     Medarex was bought out by Bristol Myers Squibb who thereupon re-named it for their co. as BMS.  Meanwhile it was developed and sold in 3 Asian countries by Ono Pharmaceuticals who, of curse, labelled it ONO.  Meanwhile, the assignment of an official generic name was in progress and this emerged last year as "nivolumab".  It will continue to be so called as a chemical name but doubtless after it gains FDA approval (it seems highly improbable that it won't!!) the manufacturers will invent brand names for it.  I say names becaus if the present licence arrangement continues it will be going out from separate makers in east and west.

    I hope this clears it up for you and I hope you stay well and continue to save money on car insurance.  Laughing

    Drug names/trials?

    When will I learn there is no need to ask Google when there's Wedgie to ask? Thank you Tex for such a thorough explanation.

  • Darron
    Darron Member Posts: 310 Member

    ?

    Am I losing it more than I realised or were you on something when you composed that message Darron? Smile

    Auto correct

    I'll edit, I typed on my phone in a hurry and the darn auto spell check makes me seem drunks sometimes!!!!