MDX-1106, part three

13

Comments

  • Texas_wedge
    Texas_wedge Member Posts: 2,798
    garym said:

    Mr. Grimm...
    You'd look too much like the Reaper in a burka...on second thought maybe you'd like that hmmmm?

    Votrient AND MDX-1106
    You made a smart move Fox in passing up the Votrient trial and going for the MDX one.

    Ironically, though, now there's someone (per KIDNEY-ONC) who is doing very well on the combination of MDX-1106 with Votrient! I'm going to keep an eye on how he progresses. From what I gather he's the first to be on MDX-1106 and Votrient at the same time, the theory being that they'll work synergistically and attack the cancer on the two fronts - anti-PD1 monoclonal antibody and anti-angiogenic. He's previously been on Sutent last Fall when he put on 30 lbs but since then he's now lost 35 lbs. He's chronicling his progress after the fashion of the brilliant writing by Chris Battle who had to decide between Sutent, IL2 and MDX-1106 just over a year ago, as narrated so absorbingly in the Cancer Chronicles at:

    http://kidneycancerchronicles.com/is-mdx-1106-the-next-big-thing-for-kidney-cancer/

    Like you, Chris Lawing is blond and radiant! I bet his nurse also says "You are my sunshine" too!? The similarities probably don't end there. Another patient has just compared notes - she was on Votrient and is now on MDX-1106 and says she had many of the side-effects of Votrient but next to none on MDX (just a little fatigue). She is speculating that her excellent latest scans are due to the MDX rather than the Votrient and shares the view that things are really looking up.
  • foxhd
    foxhd Member Posts: 3,181 Member

    Votrient AND MDX-1106
    You made a smart move Fox in passing up the Votrient trial and going for the MDX one.

    Ironically, though, now there's someone (per KIDNEY-ONC) who is doing very well on the combination of MDX-1106 with Votrient! I'm going to keep an eye on how he progresses. From what I gather he's the first to be on MDX-1106 and Votrient at the same time, the theory being that they'll work synergistically and attack the cancer on the two fronts - anti-PD1 monoclonal antibody and anti-angiogenic. He's previously been on Sutent last Fall when he put on 30 lbs but since then he's now lost 35 lbs. He's chronicling his progress after the fashion of the brilliant writing by Chris Battle who had to decide between Sutent, IL2 and MDX-1106 just over a year ago, as narrated so absorbingly in the Cancer Chronicles at:

    http://kidneycancerchronicles.com/is-mdx-1106-the-next-big-thing-for-kidney-cancer/

    Like you, Chris Lawing is blond and radiant! I bet his nurse also says "You are my sunshine" too!? The similarities probably don't end there. Another patient has just compared notes - she was on Votrient and is now on MDX-1106 and says she had many of the side-effects of Votrient but next to none on MDX (just a little fatigue). She is speculating that her excellent latest scans are due to the MDX rather than the Votrient and shares the view that things are really looking up.

    MDX
    .Have to admit,...I got lucky. I think my only side effect is that I can get pretty tired. But like you Wedgie, I can probably do more feeling crappy than most do feeling well. I am still so active, I don't think I would want an anti- angiogenic yet,since the MDX is working so well. My response over the past several months is gonna make some one rich. And that is OK with me. I can imagine how effective adding some votrient will be for alot of people. Super concept.....Can you imagine if this is the breakthrough everyone wants? Awesome!!!
  • Texas_wedge
    Texas_wedge Member Posts: 2,798
    foxhd said:

    MDX
    .Have to admit,...I got lucky. I think my only side effect is that I can get pretty tired. But like you Wedgie, I can probably do more feeling crappy than most do feeling well. I am still so active, I don't think I would want an anti- angiogenic yet,since the MDX is working so well. My response over the past several months is gonna make some one rich. And that is OK with me. I can imagine how effective adding some votrient will be for alot of people. Super concept.....Can you imagine if this is the breakthrough everyone wants? Awesome!!!

    MDX
    Awesome is the only word for it.
  • garym
    garym Member Posts: 1,647

    MDX
    Awesome is the only word for it.

    MDX...
    EFFING AWESOME!!! works too
  • alice124
    alice124 Member Posts: 896 Member

    Votrient AND MDX-1106
    You made a smart move Fox in passing up the Votrient trial and going for the MDX one.

    Ironically, though, now there's someone (per KIDNEY-ONC) who is doing very well on the combination of MDX-1106 with Votrient! I'm going to keep an eye on how he progresses. From what I gather he's the first to be on MDX-1106 and Votrient at the same time, the theory being that they'll work synergistically and attack the cancer on the two fronts - anti-PD1 monoclonal antibody and anti-angiogenic. He's previously been on Sutent last Fall when he put on 30 lbs but since then he's now lost 35 lbs. He's chronicling his progress after the fashion of the brilliant writing by Chris Battle who had to decide between Sutent, IL2 and MDX-1106 just over a year ago, as narrated so absorbingly in the Cancer Chronicles at:

    http://kidneycancerchronicles.com/is-mdx-1106-the-next-big-thing-for-kidney-cancer/

    Like you, Chris Lawing is blond and radiant! I bet his nurse also says "You are my sunshine" too!? The similarities probably don't end there. Another patient has just compared notes - she was on Votrient and is now on MDX-1106 and says she had many of the side-effects of Votrient but next to none on MDX (just a little fatigue). She is speculating that her excellent latest scans are due to the MDX rather than the Votrient and shares the view that things are really looking up.

    MDX 1106 & Votrient
    Tex,

    I can't seem to find Chris Lawing's posts that you note above. I'm familiar and a big fan of Chris Battle but haven't heard of Chris Lawing before now. Do you have a link or any other info?
  • Texas_wedge
    Texas_wedge Member Posts: 2,798
    alice124 said:

    MDX 1106 & Votrient
    Tex,

    I can't seem to find Chris Lawing's posts that you note above. I'm familiar and a big fan of Chris Battle but haven't heard of Chris Lawing before now. Do you have a link or any other info?

    Posts on MDX + Votrient
    Alice, try his post there on 1/5/12 for starters. If you don't find it rapidly, let me know and I'll pmail you a url.
  • sunlover_56
    sunlover_56 Member Posts: 110
    foxhd said:

    MDX
    .Have to admit,...I got lucky. I think my only side effect is that I can get pretty tired. But like you Wedgie, I can probably do more feeling crappy than most do feeling well. I am still so active, I don't think I would want an anti- angiogenic yet,since the MDX is working so well. My response over the past several months is gonna make some one rich. And that is OK with me. I can imagine how effective adding some votrient will be for alot of people. Super concept.....Can you imagine if this is the breakthrough everyone wants? Awesome!!!

    I am so happy for you ((((
    I am so happy for you (((( Fox))))) and I will remember MDX-1106!!
  • foxhd
    foxhd Member Posts: 3,181 Member

    Posts on MDX + Votrient
    Alice, try his post there on 1/5/12 for starters. If you don't find it rapidly, let me know and I'll pmail you a url.

    part 3
    Will be ending this part soon. Scan this Friday. Results weds. the 30th. Will probably add the recent diagnosis of both basal cell and melanoma cancer to my journey.
  • matchframe
    matchframe Member Posts: 58
    foxhd said:

    part 3
    Will be ending this part soon. Scan this Friday. Results weds. the 30th. Will probably add the recent diagnosis of both basal cell and melanoma cancer to my journey.

    Awesome!!
    I just read through the whole thread and all I can say is Awesome!! Looking forward to hearing your results on the 30th!!
  • feistyD
    feistyD Member Posts: 21
    foxhd said:

    part 3
    Will be ending this part soon. Scan this Friday. Results weds. the 30th. Will probably add the recent diagnosis of both basal cell and melanoma cancer to my journey.

    MK 3475
    Hi, I am just starting a clinical trial with MK-3475, which my doctor says is very similar to MDX-1106. I am in Part C of the trial, which is for NSCLC (non-small cell lung cancer). I just wanted to say it is very encouraging to read your story. I haven't found anyone else on my trial yet (it just started) so I am excited to learn about your results, albeit with a different drug and a different cancer. It's the same mode of treatment, however (anti PD-1). I too don't really have any side effects except some slight fatigue. Won't know if it's working for a while, so in the meantime I will just keep active and positive. Continued good luck to you!
  • foxhd
    foxhd Member Posts: 3,181 Member
    feistyD said:

    MK 3475
    Hi, I am just starting a clinical trial with MK-3475, which my doctor says is very similar to MDX-1106. I am in Part C of the trial, which is for NSCLC (non-small cell lung cancer). I just wanted to say it is very encouraging to read your story. I haven't found anyone else on my trial yet (it just started) so I am excited to learn about your results, albeit with a different drug and a different cancer. It's the same mode of treatment, however (anti PD-1). I too don't really have any side effects except some slight fatigue. Won't know if it's working for a while, so in the meantime I will just keep active and positive. Continued good luck to you!

    .Same to you feistyD!.Anti
    .Same to you feistyD!.Anti PD-1 may be the ticket. Stay positive. Any negative thoughts are a waste of good energy. Life is for the living.
  • alice124
    alice124 Member Posts: 896 Member
    foxhd said:

    MDX
    .Have to admit,...I got lucky. I think my only side effect is that I can get pretty tired. But like you Wedgie, I can probably do more feeling crappy than most do feeling well. I am still so active, I don't think I would want an anti- angiogenic yet,since the MDX is working so well. My response over the past several months is gonna make some one rich. And that is OK with me. I can imagine how effective adding some votrient will be for alot of people. Super concept.....Can you imagine if this is the breakthrough everyone wants? Awesome!!!

    Tomorrow's results
    Fox - Just want you to know I'm pulling for a fantastic report tommorrow. Know you're in my thoughts and prayers.

    Tex - If you're reading this, ditto. I know you mentioned end of the month for your scan but wasn't sure of exact date.

    P.S. You both may want to start a new thread because we'll all be racing to read!
  • foxhd
    foxhd Member Posts: 3,181 Member
    alice124 said:

    Tomorrow's results
    Fox - Just want you to know I'm pulling for a fantastic report tommorrow. Know you're in my thoughts and prayers.

    Tex - If you're reading this, ditto. I know you mentioned end of the month for your scan but wasn't sure of exact date.

    P.S. You both may want to start a new thread because we'll all be racing to read!

    tomorrows results.
    Yes. Tomorrow starts MDX part 4. I have my blood work, infusion and scan results tomorrow. What a trip. Thanks for your support Alice. still can't comprehend all of this at times.
  • Texas_wedge
    Texas_wedge Member Posts: 2,798
    foxhd said:

    tomorrows results.
    Yes. Tomorrow starts MDX part 4. I have my blood work, infusion and scan results tomorrow. What a trip. Thanks for your support Alice. still can't comprehend all of this at times.

    tomorrow's results
    I guess we all know that feeling. Let's hope MDX part 4 is going to be even more pleasing than earlier chapters.

    Alice, I've had my CT brought forward and it's now to be on Friday morning. As soon as it's over (plus a few minutes in case I have an adverse reaction to the dye) I'll be driving 500 miles, taking my Wife to see her cousin in London who we hope will still be alive on Saturday. He has had long-term malignant melanoma metastasised to liver and lately to his brain so he's undergone WBRT and was to have CyberKnife, I believe, but that has been called off due to seizures.

    Fox is moving steadily in the right direction. I may be about to go the opposite way, in which case my habitual bullishness may take a bit of a knock but, like John, I'll deal with that the best way I can.
  • sunlover_56
    sunlover_56 Member Posts: 110

    tomorrow's results
    I guess we all know that feeling. Let's hope MDX part 4 is going to be even more pleasing than earlier chapters.

    Alice, I've had my CT brought forward and it's now to be on Friday morning. As soon as it's over (plus a few minutes in case I have an adverse reaction to the dye) I'll be driving 500 miles, taking my Wife to see her cousin in London who we hope will still be alive on Saturday. He has had long-term malignant melanoma metastasised to liver and lately to his brain so he's undergone WBRT and was to have CyberKnife, I believe, but that has been called off due to seizures.

    Fox is moving steadily in the right direction. I may be about to go the opposite way, in which case my habitual bullishness may take a bit of a knock but, like John, I'll deal with that the best way I can.

    Tex
    I am wishing the best for you, your wife and her cousin. You and your family have and are going though so much. I am not the best at comforting people but I want you to know that I am thinking about all of you and hoping things come out well (((( Tex & Family )))))
    ~Judy~
  • sunlover_56
    sunlover_56 Member Posts: 110
    foxhd said:

    .Same to you feistyD!.Anti
    .Same to you feistyD!.Anti PD-1 may be the ticket. Stay positive. Any negative thoughts are a waste of good energy. Life is for the living.

    fox
    I agree, negativity is a waste of time. Hoping for the best with you and your results on the 30th!!
  • garym
    garym Member Posts: 1,647

    tomorrow's results
    I guess we all know that feeling. Let's hope MDX part 4 is going to be even more pleasing than earlier chapters.

    Alice, I've had my CT brought forward and it's now to be on Friday morning. As soon as it's over (plus a few minutes in case I have an adverse reaction to the dye) I'll be driving 500 miles, taking my Wife to see her cousin in London who we hope will still be alive on Saturday. He has had long-term malignant melanoma metastasised to liver and lately to his brain so he's undergone WBRT and was to have CyberKnife, I believe, but that has been called off due to seizures.

    Fox is moving steadily in the right direction. I may be about to go the opposite way, in which case my habitual bullishness may take a bit of a knock but, like John, I'll deal with that the best way I can.

    Tomorrow and Friday's results...
    Fox & TW,

    Being the prognosticator of all things worldly that I am, I foresee nothing but good reports for you both in the near future. MDX and MAARS are working their magic, that's my story and I'm sticking to it!
  • Texas_wedge
    Texas_wedge Member Posts: 2,798
    garym said:

    Tomorrow and Friday's results...
    Fox & TW,

    Being the prognosticator of all things worldly that I am, I foresee nothing but good reports for you both in the near future. MDX and MAARS are working their magic, that's my story and I'm sticking to it!

    Thank goodness, Prognosticator, I wasn't sure, so that's a great relief.
  • alice124
    alice124 Member Posts: 896 Member

    tomorrow's results
    I guess we all know that feeling. Let's hope MDX part 4 is going to be even more pleasing than earlier chapters.

    Alice, I've had my CT brought forward and it's now to be on Friday morning. As soon as it's over (plus a few minutes in case I have an adverse reaction to the dye) I'll be driving 500 miles, taking my Wife to see her cousin in London who we hope will still be alive on Saturday. He has had long-term malignant melanoma metastasised to liver and lately to his brain so he's undergone WBRT and was to have CyberKnife, I believe, but that has been called off due to seizures.

    Fox is moving steadily in the right direction. I may be about to go the opposite way, in which case my habitual bullishness may take a bit of a knock but, like John, I'll deal with that the best way I can.

    Tomorrow's results
    Tex,

    I'm sorry that family health also is an issue you must deal with. I can tell by your posting that you're a bit down, only to be expected as you've expressed your fondness of your wife's cousin in earlier postings. Wishing you the best in a bad situation.

    But PLEASE don't lose your FIGHT gene and that "habitual bullishness" we all love. I'm counting on two for two in good reports (you and Fox)!
  • Texas_wedge
    Texas_wedge Member Posts: 2,798
    alice124 said:

    Tomorrow's results
    Tex,

    I'm sorry that family health also is an issue you must deal with. I can tell by your posting that you're a bit down, only to be expected as you've expressed your fondness of your wife's cousin in earlier postings. Wishing you the best in a bad situation.

    But PLEASE don't lose your FIGHT gene and that "habitual bullishness" we all love. I'm counting on two for two in good reports (you and Fox)!

    Alice, both Fox and I were keen to oblige and now, with his results in, it's one down, one to go, where, of course, "down" is up and "one to go" is one to not go :-)